Combined Technical (NG) • 2026 • Paper-IV (Technical Subject)
Which term best describes the preservation of data accuracy and completeness in GLP?
A)
Data obfuscation
B)
Data integrity
C)
Data disposal
D)
Data anonymity
Option B is correct: Data integrity.
Combined Technical (NG) • 2026 • Paper-IV (Technical Subject)
Which type of necrosis is typically seen in the brain following an ischemic event (stroke)?
A)
Coagulative necrosis
B)
Caseous necrosis
C)
Fat necrosis
D)
Liquefactive necrosis
Option D is correct: Liquefactive necrosis.
Combined Technical (NG) • 2026 • Paper-IV (Technical Subject)
In H&E staining, what does haematoxylin primarily stain on the cellular structure?
A)
Cytoplasm
B)
Lipids
C)
Cell membrane
D)
Nucleus
Option D is correct: Nucleus.
Combined Technical (NG) • 2026 • Paper-IV (Technical Subject)
Which laboratory test is commonly used to monitor the extrinsic pathway of the coagulation cascade?
A)
Prothrombin Time (PT)
B)
Activated Partial Thromboplastin Time (APTT)
C)
Thrombin Time (TT)
D)
Bleeding Time (BT)
Option A is correct: Prothrombin Time (PT).
Combined Technical (NG) • 2026 • Paper-IV (Technical Subject)
The D-dimer test is elevated in DIC because it measures:
A)
The number of RBCs
B)
Clotting factor activity
C)
Products of fibrin breakdown
D)
The level of oxygen in the blood
D-dimer is a degradation product formed when cross-linked fibrin is broken down by plasmin. In DIC, widespread clot formation occurs followed by fibrinolysis, so D-dimer levels rise due to increased fibrin breakdown products. RBC count, clotting factor activity, and blood oxygen level are not what D-dimer specifically measures.
Combined Technical (NG) • 2026 • Paper-IV (Technical Subject)
What do the azures in Romanowsky stains bind to in the cell?
A)
Acidic components
B)
Basic components
C)
Neutral components
D)
Both acidic and neutral components equally
Option A is correct: Acidic components.
Combined Technical (NG) • 2026 • Paper-IV (Technical Subject)
Most blood group system are inherited as:
A)
Sex linked
B)
Autosomal codominant
C)
Autosomal dominant
D)
Autosomal recessive
Option B is correct: Autosomal codominant.
Combined Technical (NG) • 2026 • Paper-IV (Technical Subject)
What does a high Red Cell Distribution Width (RDW) indicate?
A)
All red blood cells are the same size
B)
There is a high degree of variation in red blood cell size
C)
The patient has macrocytic anemia
D)
The patient has microcytic anemia
Option B is correct: There is a high degree of variation in red blood cell size.
Combined Technical (NG) • 2026 • Paper-IV (Technical Subject)
What is the primary fixative used for most cytological smears?
A)
Alcohol
B)
Acetone
C)
Formalin
D)
Glutaraldehyde
Option A is correct: Alcohol.
Combined Technical (NG) • 2026 • Paper-IV (Technical Subject)
Which of the following protein is anti-apoptotic?
A)
Bim
B)
Bid
C)
Bcl-Xs
D)
Bfl-1
Bfl-1 (also called A1) is an anti-apoptotic member of the Bcl-2 family. It helps prevent programmed cell death by inhibiting pro-apoptotic signaling. In contrast, Bim and Bid are pro-apoptotic BH3-only proteins, and Bcl-Xs is the pro-apoptotic splice variant of Bcl-x. Therefore, the anti-apoptotic protein among the options is Bfl-1.
Combined Technical (NG) • 2026 • Paper-IV (Technical Subject)
When WBC’s are counted manually by Turks fluid, blood is diluted by ratio:
A)
1:20
B)
1:50
C)
1:100
D)
1:200
Option A is correct: 1:20.
Combined Technical (NG) • 2026 • Paper-IV (Technical Subject)
What is the effect of over-decalcification?
A)
Better sectioning
B)
Improved staining
C)
Loss of nuclear staining
D)
Enhanced antigenicity
Option C is correct: Loss of nuclear staining.
Combined Technical (NG) • 2026 • Paper-IV (Technical Subject)
Prussian blue stain is used for:
A)
Iron
B)
Hemosiderin
C)
Glycogen
D)
Bacteria
Option B is correct: Hemosiderin.
Combined Technical (NG) • 2026 • Paper-IV (Technical Subject)
The ration of blood to tri sodium for prothrombin time:
A)
9:1
B)
1:9
C)
1:4
D)
4:1
Option A is correct: 9:1.
Combined Technical (NG) • 2026 • Paper-IV (Technical Subject)
Bleeding time is prolonged in:
A)
Factor VIII deficiency
B)
Christmas factor deficiency
C)
Von willebrand disease
D)
Vitamin K deficiency
Option C is correct: Von willebrand disease.
Combined Technical (NG) • 2026 • Paper-IV (Technical Subject)
An automated haematology cell counter use the principle of:
A)
diffusion
B)
colour absorption changes
C)
electrical impedence
D)
wave frequency
Option C is correct: electrical impedence.
Combined Technical (NG) • 2026 • Paper-IV (Technical Subject)
In cytology which technique improves sample quality and allows for additional testing?
A)
Conventional smear method
B)
Cyto-centrifugation
C)
Manual slide staining
D)
Liquid based cytology (LBC)
Liquid based cytology (LBC) improves sample quality by reducing obscuring material such as blood, mucus, and debris, and it creates a more uniform cell preparation. It also preserves part of the sample in liquid medium, allowing additional testing like HPV testing or other ancillary studies. Conventional smear method does not provide this advantage, cyto-centrifugation mainly concentrates cells but is not specifically designed for broader additional testing, and manual slide staining is only a staining step, not a sample-processing technique.
Combined Technical (NG) • 2026 • Paper-IV (Technical Subject)
Gram staining is a type of:
A)
Acid-fast staining
B)
Simple staining
C)
Negative staining
D)
Differential staining
Option D is correct: Differential staining.
Combined Technical (NG) • 2026 • Paper-IV (Technical Subject)
Aspiration cytology of lung is usually carried out under:
A)
Television fluoroscopy
B)
Ultrasound guidance
C)
CT guided
D)
Surgical intervention
Aspiration cytology of the lung is most commonly done under CT guidance because CT provides precise visualization of the lesion, helps avoid blood vessels and vital structures, and improves needle placement in deep pulmonary lesions. Ultrasound guidance is generally useful for superficial or pleural-based lesions, not most lung parenchymal lesions. Television fluoroscopy is older and less accurate for localizing many lung masses. Surgical intervention is not the usual method for aspiration cytology.
Combined Technical (NG) • 2026 • Paper-IV (Technical Subject)
Nitrite in a urine specimen suggest the presence of:
A)
White blood cell
B)
Red blood cell
C)
Bacteria
D)
Yeast
Option C is correct: Bacteria.
Combined Technical (NG) • 2026 • Paper-IV (Technical Subject)
What is a characteristic of a benign neoplasm?
A)
Metastasis to distant sites
B)
Invasion of surrounding tissue
C)
Rapid, uncontrolled growth
D)
It does not spread and usually has a more favorable prognosis
A benign neoplasm is non-cancerous. It typically grows slowly, remains localized, and does not metastasize to distant sites. Option (d) correctly describes this behavior and its generally good prognosis. Options (a) and (b) are features of malignant tumors, and (c) is more characteristic of malignant or aggressive neoplasms rather than benign ones.
Combined Technical (NG) • 2026 • Paper-IV (Technical Subject)
Which of the following is an example of exfoliative cytology?
A)
Bronchoalveolar lavage
B)
FNAC
C)
Biopsy
D)
Bone marrow aspiration
Exfoliative cytology studies cells shed or washed off from body surfaces and cavities. Bronchoalveolar lavage collects cells from the lining of the bronchioles and alveoli by washing them out, so it is an example of exfoliative cytology. FNAC and bone marrow aspiration are aspiration cytology techniques, while biopsy is a tissue-based histopathological examination, not cytology.
Combined Technical (NG) • 2026 • Paper-IV (Technical Subject)
What is the purpose of acid alcohol in Ziehl Neelsen staining process?
A)
To fix the smear
B)
To decolorize non acid fast organism
C)
To heat the slide
D)
To counterstain the background
Option B is correct: To decolorize non acid fast organism.
Combined Technical (NG) • 2026 • Paper-IV (Technical Subject)
The term for abnormal morphology of sperm in ejaculate for sperm analysis is:
A)
Azoospermia
B)
Asthenozoospermia
C)
Teratozoospermia
D)
Oligozoospermia
Option C is correct: Teratozoospermia.
Combined Technical (NG) • 2026 • Paper-IV (Technical Subject)
What is the name of the gaps in the myelin sheath where the nerve impulse jumps during saltatory conduction?
A)
Synapse
B)
Nodes of Ranvier
C)
Axon terminals
D)
Cell body
Option B is correct: Nodes of Ranvier.
